PROBLEM TO BE SOLVED: To provide a completely human monoclonal antibody which specifically binds to interleukin 1α. Full human monoclonal antibodies have (i) an antigen-binding variable region that exhibits a very high binding affinity for interleukin 1α, and (ii) activation of the complement system through C1q binding and several different Fc. Includes constant regions that are effective in any of the bindings to the receptor. [Selection diagram] None【課題】インターロイキン１αに特異的に結合する完全なヒトモノクローナル抗体の提供。【解決手段】完全なヒトモノクローナル抗体は、（ｉ）インターロイキン１αに対する非常に高い結合親和性を示す抗原結合可変領域と、（ｉｉ）Ｃ１ｑ結合を通じた補体系の活性化及びいくつかの異なるＦｃ受容体への結合のいずれにおいても有効な定常領域とを含む。【選択図】なし
