Ralph Minter,Julie Douthwaite,Jacques Moisan,Michael Bowen,Steven Rust,Cyril Privezentzev
申请号：
US14399685
公开号：
US09884902B2
申请日:
2013.03.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.
