KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION;고려대학교산학협력단
发明人:
KIM, Won Ki,김원기,CHOI, YongSeok,최용석
申请号：
KRKR2014/006354
公开号：
WO2015/009008A1
申请日:
2014.07.15
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a novel adenine derivative and a pharmaceutical use thereof and, more specifically, to a novel adenine derivative having a structure of chemical formula 1 or a pharmaceutically acceptable salt thereof and to a composition for preventing or treating degenerative brain disease, the composition containing the novel adenine derivative or the pharmaceutically acceptable salt thereof. The novel adenine derivative and the pharmaceutically acceptable salt thereof according to the present invention are adenosine A3 receptor agonists, and have an action of inhibiting the migration or infiltration of inflammatory cells (microglia, macrophages, neutrophils, etc.), to disease areas and the activities thereof. In addition, the adenine derivative according to the present invention was verified to suppress and treat brain injury more remarkably compared with the known adenosine A3 receptor agonists in a cerebral ischemia experimental model, exhibit significant effects by drug administration 10 hours after cerebral infarction, and allow long-term survival despite brain injury due to cerebral ischemia, and thus can be useful as an agent for treating and preventing degenerative brain disease including a stroke.La présente invention porte sur un nouveau dérivé de l'adénine et sur son utilisation pharmaceutique, et plus précisément sur un nouveau dérivé de l'adénine ayant une structure ayant la formule chimique 1 ou un sel pharmaceutiquement acceptable de ce dernier, ainsi que sur une composition pour prévenir ou traiter une maladie dégénérative du cerveau, la composition contenant le nouveau dérivé de l'adénine ou le sel pharmaceutiquement acceptable de ce dernier. Le nouveau dérivé de l'adénine et le sel pharmaceutiquement acceptable de ce dernier selon la présente invention sont des agonistes du récepteur A3 de l'adénosine et ont une action d'inhibition de la migration ou de l'infiltration de cellules inflammatoires (microglies, macrophages, neutrophi
