New derivatives of N- (2,3-dihydro-1H-pyrrolo [2,3-b] pyridin-5-yl) -4-quinazolinamine and N- (2,3-dihydro-1H-indole-5-yl) -4-quinazolinamine as PERK inhibitors
A compound of Formula (I) ** Formula ** a tautomer or a stereoisomeric form thereof, wherein R1 is -Ar1, -O-Ar1 or -NH-Ar1； Ar1 is phenyl, pyridinyl, indazolyl, pyrazolyl, indolyl, imidazolyl, benzimidazolyl, thienyl, quinazolinyl, benzo [b] thienyl, benzofuranyl, 1H-pyrrolo [2,3-b] pyridinyl, imidazo [1,2-a] pyridinyl, 1,3-dihydro-1-oxo-2H-isoindolyl, 1,3-dihydro-1,3-dioxo-2H-isoindolyl, naphthyl, isoquinolinyl, quinolinyl, cinolinyl, furanyl or 2,3-dihydro-2-oxo- 1H-benzimidazolyl； each optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of C1-4 alkyl, C1-4 alkylcarbonyl, C1-4 alkyloxy, halo, Ar2 and C1-4 alkyl substituted with one or more atoms halo； Ar2 is phenyl, thienyl, furanyl, isoxazolyl, oxazolyl or pyrazolyl； each optionally substituted with 1, 2 or 3 C1-4 alkyl groups； R2 and R3 are the same and are hydrogen or fluoro； A is CH or N； R4 is hydrogen, chlorine or fluoro； R5 is hydrogen, -OR7 or -O- (CH2) m-O-R7； R6 is hydrogen, -OR8 or -O- (CH2) m-O-R8； with the proviso that at least one of R5 and R6 is not hydrogen； or R5 and R6 are taken together to form the bivalent radical -O- (CH2) n-O-； n is 1, 2 or 3； m is 1, 2, 3 or 4； R7 is C1-4 alkyl optionally substituted with an NR9aR10a； R8 is C1-4 alkyl optionally substituted with an NR9bR10b； R9a and R10a are each independently hydrogen or C1-4 alkyl； or R9a and R10a are taken together with the nitrogen to which they are bound to form a saturated monocyclic heterocycle of 4, 5, 6 or 7 members which may also contain an additional heteroatom selected from O, S, S (>； = O) by N ； and heterocycle which may be optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of halo and C1-4 alkyl； R9b and R10b are each independently hydrogen or C1-4 alkyl； or R9b and R10b are taken together with the nitrogen to which they are bound to form a saturated monocyclic heterocycle of 4, 5, 6 or 7 members which may also contain
