A laminated gasket to be inserted in a syringe barrel prevents leakage of a highly permeable liquid drug which may otherwise occur when an inert film of the gasket does not intimately contact an inner wall of the syringe barrel. The laminated gasket has a circumferential surface portion , a liquid contact surface, a bottom surface , and a threaded hole adapted to be in threaded engagement with a distal end portion of a plunger. The threaded hole has an internal thread provided on an inner peripheral surface thereof and including a plurality of periodic thread portions. Provided that an innermost periodic internal thread portion has a diameter Fl, that the other periodic internal thread portions each have a diameter F2 and that a distal one of periodic thread portions of an external thread provided on the distal end portion of the plunger has a diameter D1, a relationship F2>；D1>；F1 is satisfied.
