A laminated gasket to be inserted in a syringe barrel is provided, which prevents leakage of a highly permeable liquid drug which may otherwise occur when an inert film of the gasket does not intimately contact an inner wall of the syringe barrel. The inventive laminated gasket has a circumferential surface portion (17) to be kept in contact with an inner peripheral surface (16) of a syringe barrel (11), a liquid contact surface connected to one edge of the circumferential surface portion, a bottom surface (20) provided on the other edge side of the circumferential surface portion, and a threaded hole (21) extending from a center of the bottom surface (20) into a main body and adapted to be in threaded engagement with a distal end portion (18) of a plunger (12). The threaded hole (21) has an internal thread provided on an inner peripheral surface thereof as extending from a mouth thereof toward an innermost portion (22) thereof and including a plurality of periodic thread portions. Provided that at least an innermost one of the periodic internal thread portions adjacent to the innermost portion (22) of the threaded hole has a diameter F1, that the other periodic internal thread portions each have a diameter F2 and that at least a distal one of periodic thread portions of an external thread provided on the distal end portion of the plunger (12) has a diameter D1, a relationship F2 >； D1 >； F1 is satisfied.
