人類組織因子抗體及其用途农业专利-农业专业知识服务系统

发明人:: ALMAGRO, JUAN CARLOS,阿尔马格罗　裘,阿爾馬格羅　裘,ANDERSON, GLENN MARK,安德森　格伦,安德森　格倫,CHI, ELLEN,齐　爱伦,齊　愛倫,MARTINEZ, CHRISTIAN,马丁内斯　克利斯汀,馬丁內斯　克利斯汀,RAGHUNATHAN, GOPALAN,拉赫胡纳森　戈巴兰,拉赫胡納森　戈巴蘭,SWANSON, RONALD,史旺森　罗纳度,史旺,阿尔马格罗裘,阿爾馬格羅裘,安德森格伦,安德森格倫,齐爱伦,齊愛倫,马丁内斯克利斯汀,馬丁內斯克利斯汀,拉赫胡纳森戈巴兰,拉赫胡納森戈巴蘭,史旺森罗纳度

摘要：: The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.本發明是關於一種人類型抗體，其能夠避免組織因子(凝血因子F3)訊息傳遞，但不會防礙對組織因子的因子VII結合和FX結合且不會延長凝血時間。本發明的抗體係用於治療，例如腫瘤進展的症狀，其中相關細胞會表現組織因子且組織因子訊息傳遞發生。