Alexey Teplyakov;Juan Carlos Almagro;Sheng-Jiun Wu;Glenn Mark Anderson;Ronald Swanson;Hong Mimi Zhou;Kam-Fai Tse;Christian Martinez;Ellen Chi;Gopalan Raghunathan
发明人:
Juan Carlos Almagro,Glenn Mark Anderson,Ellen Chi,Christian Martinez,Gopalan Raghunathan,Ronald Swanson,Alexey Teplyakov,Kam-Fai Tse,Sheng-Jiun Wu,Hong Mimi Zhou
申请号：
US13398881
公开号：
US20120237528A1
申请日:
2012.02.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
