Juan Carlos Almagro,Glenn Mark Anderson,Ellen Chi,Christian Martinez,Gopalan Raghunathan,Ronald Swanson,Alexey Teplyakov,Kam-Fai Tse,Sheng-Jiun Wu,Hong Mimi Zhou
申请号：
US14230128
公开号：
US08999333B2
申请日:
2014.03.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
