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Peptide deformylase inhibitors
专利权人:
GLAXOSMITHKLINE LLC
发明人:
QIN, DONGHUI,NORTON, BETH,LIAO, XIANGMIN,KNOX, ANDREW,FANG, YUHONG,LEE, JINHWA,DREABIT, JASON,CHRISTENSEN, SIEGFRIED,BENOWITZ, ANDREW,AUBART, KELLY
申请号:
ES08847151
公开号:
ES2549879T3
申请日:
2008.11.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound according to Formula (I): ** Formula ** in which: R1 is - (CH2) n-C3-C6 cycloalkyl; R2 is C1-C3 alkyl; cyclopropyl; C1-C3 alkoxy; C1-C3 haloalkyl; C1-C3 sulfanyl; 5-membered heteroaryl; 5-membered heterocycloalkyl; halo; hydroxymethyl; or -NRaRb; R3 is -NR4R5 whereas R4 and R5 are linked together with the N atom to which they are coupled, forming a heterocycloalkyl group optionally substituted with one to three R6 groups; wherein each R6 is independently selected from the group consisting of C1-C6 alkyl, optionally substituted with one to three R7 groups; hydroxy; C1-C3 alkoxy; -C (O) NRaRb; - C (O) Rc; -C (O) 0Rc; heterocycloalkyl; C3-C6 cycloalkyl optionally substituted with a -NRaRb or pyrrolidinyl; oxo; cyano; -NRaRb; phenyl; heteroaryl; and halo; wherein: each R7 is independently selected from the group consisting of hydroxy; C1-C3 alkoxy; halo; phenyl; cyano; -NRaRb; -C (O) NRaRb; -C (O) Rc; C3-C6 cycloalkyl, optionally substituted with a hydroxy, heterocycloalkyl or -NRaRb group; heterocycloalkyl; and heteroaryl optionally substituted with a methyl, NRaRb or hydroxy; each Ra is independently selected from H and C1-C3 alkyl optionally substituted with a hydroxy, methoxy or dimethylamine; each Rb is independently selected from H and C1-C3 alkyl; each Rc is independently selected from C1-C3 alkyl optionally substituted with a methoxy; phenyl; heterocycloalkyl; and heteroaryl; n is an integer from 0 to 2; or a salt thereof.Un compuesto de acuerdo con la Fórmula (I):**Fórmula** en la que: R1 es -(CH2)n-cicloalquilo C3-C6; R2 es alquilo C1-C3; ciclopropilo; alcoxi C1-C3; haloalquilo C1-C3; sulfanilo C1-C3; heteroarilo de 5 miembros; heterocicloalquilo de 5 miembros; halo; hidroximetilo; o -NRaRb; R3 es -NR4R5 wherein R4 y R5 están unidos junto con el átomo de N al que están acoplados, formando un un grupo heterocicloalquilo opcionalmente sustituido con uno a tres grupos R6; en el que cada R6 se selecciona independientemente entre el grupo que consiste en
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