The invention relates to cis-tetrahydro-spiro(cyclohexane-1,1’-pyrido[3,4-b]indole)-4-amin derivatives which act on the nociceptin/ORL-1 receptor system as well as on the μ-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain (inter alia inflammatory pain, visceral pain, tumour pain, preferably neuropathic pain) without at the same time developing pronounced effectiveness in the case of acute, nociceptive pain.本發明關係到順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物,其作用於痛敏肽/ORL-1受體系統,並作用於微-類鴉片受體系統,尤其係其特徵係用於治療慢性疼痛(尤其係發炎性之疼痛、內臟之疼痛、腫瘤之疼痛,特別係神經病變之疼痛)時,呈現出選擇性之療效,然而不會同時對急性、感覺接受性疼痛之疼痛產生明顯之療效。
