Provided is a novel compound being useful as a mendicant such as a pain relief mendicant. This invention provides a novel histidine derivatives having excellent pain relief function, which is very useful as a pain relief mendicant for treatment of acute or chronic pain, or neuropathic pain.本發明提供一種可使用作為鎮痛藥等醫藥的新穎化合物。本發明提供具有優異鎮痛作用等的新穎組胺酸衍生物,非常適用於作為治療急性或慢性疼痛、神經病變性疼痛用之鎮痛藥等。