CRYSTALLINIC FORMS OF 4 - [(2,4-DICHLOR-5-METHOXYPHENYL) AMINO] -6-METHOXY-7- [3- (4-METHYL-1-PIPERAZINYL) PROPOXY] -3-QUINOLINCARBONITRIL AND PROCEDURES FOR PREPARATION

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专利权人:

WYETH LLC

发明人:

TESCONI, MARC, SADLER,FEIGELSON, GREGG,STRONG, HENRY,WEN, HONG

申请号：

DK06774184

公开号：

DK1902029T3

申请日:

2006.06.28

申请国别(地区):

DK

年份:

2014

代理人:

摘要：

This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2&thetas； angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.

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