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Phenanthroindolizidine compound and NFkB inhibitor containing the same as active ingredient
专利权人:
KABUSHIKI KAISHA YAKULT HONSHA
发明人:
IKEDA, TAKASHI,SAWADA, SEIGO,YAEGASHI, TAKASHI,MATSUZAKI, TAKESHI,HASHIMOTO, SHUSUKE,YAMAZAKI, RYUTA
申请号:
ES09821827
公开号:
ES2541589T3
申请日:
2009.10.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the following formula (1) or a salt thereof: where R 1 represents a hydrogen atom, an alkyl group with a number of carbon atoms from 1 to 6, an alkyloxy group with a number of carbon atoms of 1 to 6, or a halogen atom; R2 represents a hydroxyl group, or an alkyloxy group with a number of carbon atoms of 1 to 6; R3 represents a hydrogen atom, an alkyl group with a number of carbon atoms from 1 to 6, or a halogen atom; R4 represents a hydrogen atom or an alkyloxy group with a number of carbon atoms from 1 to 6; R5 represents a hydrogen atom, an alkyloxy group with a number of carbon atoms from 1 to 6, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6, or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, an alkyloxy group with a number of carbon atoms from 1 to 6, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or an alkyl group with a number of carbon atoms from 1 to 6; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or an alkylcarbonyloxy group with a number of carbon atoms of 1 to 6; with the proviso that the following cases are excluded: the case where R1, R3, R4 and R7 are hydrogen atoms; R2 and R8 are hydroxyl groups and R5 and R6 are methoxy groups; the case where R1, R3, R4 and R7 are hydrogen atoms, R2, R5 and R6 are methoxy groups, and R8 is a hydroxyl group; the case where R1, R3, R4, R7 and R8 are hydrogen atoms and R2, R5 and R6 are methoxy groups; the case where R1, R3, R4 and R7 are hydrogen atoms, R2, R5 and R8 are hydroxyl groups, and R6 is a methoxy group; the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R6 are methoxy groups, and R5 and R8 are hydroxyl groups; the case where R1, R3, R4, R7 and R8 are hydrogen atoms, R2 and R6 are methoxy groups, and R5 is a hydroxyl group; the case where R1, R2, R5 and R6 are methoxy groups and R3, R4, R7
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