The invention relates to a process for making lipid-coated substrates comprising the steps ofa. Providing a lipid solution (A) of phospholipids in a water miscible organic solvent at a phospholipid concentration between 25 and 450 mg/ml；b. Provide an aqueous solution (B) having pH between 4 and 8；c. Agitate the aqueous solution (B) and dispense the lipid solution (A) into the aqueous solution (B) to prepare an aqueous dispersion comprising lipid vesicles (C) having a number average size between 80 and 120 nm (measured according to dynamic light scattering) at a phospholipid concentration between 0.05 mg/ml and 2 mg/ml； andd. Applying the aqueous dispersion (C) to a substrate and formation of a lipid-based coating；e. Wherein aqueous dispersion (C) contains at least 95 wt% water.The invention further relates to medical devices comprising a lipid-based coating, for example contact lenses and catheters.
