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MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION
专利权人:
发明人:
Miloud Rahmouni,Sonia Gervais,Vinayak Sant,Damon Smith,Frederic Duffayet,Shams Rustom,Ali El-Jammal,Jean-Michel Ndong,Ali Bichara
申请号:
US14305935
公开号:
US20140294955A1
申请日:
2014.06.16
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. A second layer comprises a superabsorbent material. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material creates a hard gel that traps the microparticles. The hard gel and microparticles provide controlled release of the pharmaceutically active agent.
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