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MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION
专利权人:
发明人:
Miloud Rahmouni,Sonia Gervais,Vinayak Sant,Damon Smith,Frederic Duffayet,Shams Rustom,Ali El-Jammal,Jean-Michel Ndong,Ali Bichara
申请号:
US14560933
公开号:
US20150272888A1
申请日:
2014.12.04
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. A second layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles. The composition further comprises a superabsorbent material disposed within the first layer, the second layer, or both the first layer and the second layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition.
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