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5-carbamoyl-adamantan-2-yl amide derivatives, pharmaceutically acceptable salts thereof and preparation processes thereof
专利权人:
SK Biopharmaceuticals Co.; Ltd.
发明人:
CHUNG, Coo-Min,RYU, Choon-Ho,LEE, Yoon-Kyeong,MOON, Jin-Sook,LEE, Hye-Sung,LEE, Seon-Jeong,OH, Kyung-Seok
申请号:
ES12797254
公开号:
ES2575370T3
申请日:
2012.06.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound represented by Chemical Formula I, its racemate or a pharmaceutically acceptable salt thereof: ** Formula ** wherein ring A is an aryl group or a heteroaryl group selected from the group consisting of Chemical Formulas (II) a (VIII): ** Formula ** in which X is O, S or NY, Y is selected from the group consisting of H, a linear or branched alkyl group of C1 to C5 and a cyclic alkyl group of C3 to C5 , R1, which is attached to any one of the aromatic carbons of ring A, is selected from the group consisting of H; a linear or branched C1 to C5 alkyl group; a C3 to C5 cyclic alkyl group; O-R3; - N (R4) R5; and a phenyl group, pyridine group, furan group, thiazole group, thiophene group, hydro-1H-isoquinoline group and isoxazole group, being one to three hydrogen atoms substituted with R2, R2 is selected from the group consisting of H, a halogen atom, a linear or branched alkyl group of C1 to C5, a cyclic alkyl group of C3 to C5, a trifluoromethyl group, a nitro group, -O-R6 and -N (R7) R8; R3 is selected from the group consisting of H, a linear or branched alkyl group of C1 to C4, a cyclic alkyl group of C3 to C5, a -CH2-cyclic alkyl of C5 to C6, a -CH2-aryl of C6 to C10 and a -CH2-heteroaryl of C2 to C8 with at least one of O, N and S in the aromatic ring; R4 and R5, which are the same or different from each other, are independently selected from the group consisting of H and a linear or branched C1 to C5 alkyl group, or R4 and R5 join to form a 5-7 membered ring , wherein the 5-7 member ring is an unsubstituted one or has a phenyl group as a substituent; R6 is selected from the group consisting of H and a linear or branched alkyl group of C1 to C3; and R7 and R8, which are the same or different from each other, are each independently selected from the group consisting of H and a linear or branched alkyl group of C1 to C3, or R7 and R8 are joined to form a ring of 5 -7 members.Un compuesto representado por la Fórmula Química I, su racemato o una sal farmacéut
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