PROBLEM TO BE SOLVED: To provide a nonsteroidal non-steroid anti-inflammatory drug-containing pharmaceutical composition excellent in percutaneous absorption.SOLUTION: The pharmaceutical composition for percutaneous administration includes microparticles with the average particle size of 300 nm or less obtained by mixing and grinding following components (A)-(C): (A) an anti-inflammatory drug selected from piroxicam and pranoprofen (B) a water-soluble polymer selected from hydroxypropyl methylcellulose and methylcellulose and (C) an alkyl sulfate.COPYRIGHT: (C)2013,JPO&INPIT【課題】経皮吸収性に優れた非ステロイド性抗炎症薬含有医薬組成物を提供する。【解決手段】次の成分(A)~(C)を混合粉砕して得られる平均粒子径が300nm以下の微粒子を含有する経皮投与用医薬組成物。(A)ピロキシカム及びプラノプロフェンから選ばれる抗炎症薬(B)ヒドロキシプロピルメチルセルロース及びメチルセルロースから選ばれる水溶性高分子(C)アルキル硫酸塩【選択図】なし