A COMPOSITION CONTAINING A VERY LOW WATER-SOLUBLE DRUG, WHICH COMPOSITION IS PRODUCED BY TREATING, WITH A SUPERCRITICAL OR SUBCRITICAL CARBON DIOXIDE FLUID, A MIXTURE CONTAINING A VERY LOW WATER -SOLUBLE DRUG AND A POROUS MATERIAL (EXCLUSIVE OF A POROUS SILICA MATERIAL CHARACTERIZED IN THAT THE MATERIAL HAS AN AVERAGE PORE DIAMETER OF 1 TO 20 NM, THE TOTAL PORE VOLUME OF THE MATERIAL THAT HAVE A DIAMETER FALLING WITHIN A RANGE OF ± 40% OF THE AVERAGE PORE DIAMETER ACCOUNT FOR 60% OR MORE THE VOLUME OF ALL THE PORES OF THE MATERIAL,AND, WHEN SUBJECTED TO X-RAY DIFFRACTOMETRY, THE MATERIAL EXHIBITS ONE OR MORE PEAKS AT A DIFFRACTION ANGLE (20 ) CORRESPONDING TO D OF 1NM OR MORE) AND A METHOD FOR PRODUCING THE COMPOSITION.THE VERY-LOW-WATER-SOLUBLE-DRUG-CONTAINING COMPOSITION OF THE PRESENT INVENTION ENSURES IMPROVED DISSOLUTION OF THE VERY LOW WATER-SOLUBLE DRUG.
