An elastic physiological detection structure includes a fabric article, a main body, an elastic member, and a detection module. The main body is combined with an internal layer of the fabric article. The main body includes at least one opening formed therein. The elastic member is combined to a surface of the main body. The detection module is combined to the elastic member and exposed outside the opening of the main body. The elastic member helps the detection module to apply an increased force from the fabric article to a surface layer of a human body, allowing the detection module located outside the opening of the main body to tightly engage the surface layer of the human body at a site where detection is to be made thereby improving the attachability of the detection module to the surface layer of the human body and enhancing stability of dynamic detection.