Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO
发明人:
申请号：
EP19153456.9
公开号：
EP3685746A1
申请日:
2019.01.24
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Methods and systems for measuring hemoglobin concentration (cHb). A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (λ1, λ2). The isosbestic wavelengths (λ1, λ2) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbO2,Hb) have the same molar extinction coefficient. Measurements are collected of a plurality of backscattered reflection intensities (I(xb,λ1), I(xt,λ1), I(xb,λ2), I(xt,λ2)). Preferably, the measurements are spectrally resolved at least for the two isosbestic wavelengths (λ1, λ2) and position-resolved for at least a blood vessel location (xb) coinciding with a selected blood vessel and a tissue location (xt) coinciding with the retinal tissue without blood vessel. The hemoglobin concentration (cHb) can be calculated based on a combination of the measurements at the two isosbestic wavelengths (λ1, λ2),
