The present invention relates to pyrrolidines -2,The preparation method of 5- dione compounds and these compounds. The present invention also relates to comprising pyrrolidines -2,The Pharmaceutical composition of 5- dione compounds. The present invention provides through the compounds of this invention or pyrrolidines -2 of giving therapeutically effective amount to patient in need,5- dione compounds come the method for treating cell proliferation disorders such as cancer, wherein U independently selected from:本發明涉及吡咯烷-2,5-二酮化合物和這些化合物的製備方法。本發明也涉及包含吡咯烷-2,5-二酮化合物的藥用組合物。本發明提供通過對有需要的患者給予治療有效量的本發明化合物或吡咯烷-2,5-二酮化合物來治療細胞增殖性疾病例如癌症的方法，其中U獨立地選自：
