РИД Дэвид П. (US),БАРНС Нил Р. (US),КЕЙН Джон К. (US),ЛИ Кристофер А. (US),ЧЭНЬ Цзянь-Се (US),РЕДМОНД Мартин П. (US)
申请号：
RU2012131344/04
公开号：
RU2012131344A
申请日:
2010.12.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Polymorph (-) - 3- (5,6-dihydro-4H-pyrrolo [3,2,1-] quinolin-1-yl) -4- (1H-indol-3-yl) pyrrolidine-2, 5-dione, characterized by a powder X-ray diffraction pattern including peaks at approximately 8.2, 10.8 and 14.1 22θ using Cu Kα radiation. The polymorph of claim 1, characterized by a powder X-ray diffraction pattern, comprising peaks in the range of about 8.2, 10.8, 14.1, 15.5, 17.8, 19.9 and 25.6 º2θ using Cu Kα radiation. 3. The polymorph of claim 1, characterized by a powder X-ray diffraction pattern comprising peaks in the range of about 8.2, 10.8, 14.1, 14.9, 15.5, 17.1, 17.8, 19.4, 19, 9, 21.1, 21.9, 23.0, 25.6 and 28.4 º2θ using Cu Kα radiation. Polymorph (-) - 3- (5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl) -4- (1H-indol-3-yl) pyrrolidine-2,5 -dione, characterized by a powder X-ray diffraction pattern including peaks at approximately 6.5, 9.9 and 12 22θ using Cu Kα radiation. The polymorph of claim 4, characterized by a powder X-ray diffraction pattern, comprising peaks around 6.5, 9.9, 12.0, 16.7, 20.1 and 22.8 22θ using Cu Kα radiation. The polymorph of claim 4, characterized by a powder X-ray diffraction pattern comprising peaks at about 6.5, 9.9, 12.0, 13.2, 16.4, 16.7, 17.2, 20.1, 20, 3, 20.8, 22.8, 23.7, 28.6 and 30.4 º2θ using Cu Kα radiation. (±) - 3- (5,6-dihydro-4H-pyrrolo [3,2,1- quinolin-1-yl) -4- (1H-indol-3-yl) pyrrolidin-2,5-dione dichloromethane .8. A composition comprising (±) - 3- (5,6-dihydro-4H-pyrrolo [3,2,1- quinolin-1-yl) -4- (1H-indol-3-yl) pyrrolidine-2, 5-dione-dichloromethane. The composition of claim 8, (±) -3- (5,6-dihydro-4H-pyrrolo [3,2,1- quinolin-1-yl) -4- (1H-indol-3-yl) pyrrolidin- 2,5-dione-dichloromethane. A composition according to claim 9, comprising more than 95% (±) -3- (5,6-dihydro-4H-pyrrolo [3,2,1-ij]
