The present invention relates to 1 types and 2 type polymorphs of (-)-trans- -3- (5,6- dihydro -4H- pyrrolo- [3,2,1-ij] quinoline -1- base) -4- (1H- indol-3-yl) pyrrolidine-2,5-dione. The invention further relates to have -3- (5 trans- more than (-)-of 99% chiral purity, 6- dihydro -4H- pyrrolo- [3,2,1-ij] quinoline -1- base) -4- (1H- indol-3-yl) pyrrolidines -2,5- dione compounds, and the method for preparing these compounds. The invention further relates to the pharmaceutical compositions comprising these (-)-trans- -3- (5,6- dihydro -4H- pyrrolo- [3,2,1-ij] quinoline -1- base) -4- (1H- indol-3-yl) pyrrolidine-2,5-dione compound. The present invention provides the methods for the treatment of cell proliferative disorders such as cancer, it includes to have -3- (5 trans- more than (-)-of 99% chiral purity by apply therapeutically effective amount to subject with this need, 6- dihydro -4H- pyrrolo- [3,2,1-ij] quinoline -1- base) -4- (1H- indol-3-yl) pyrrolidines -2, the composition of 5- diketone or (-)-trans- -3- (5,6- dihydro -4H- pyrrolo- [3,2,1-ij] quinoline -1- base) -4- (1H- indol-3-yl) pyrrolidines -2,5- diketone 1 type and 2 type polymorphs implement.本發明涉及(-)-反式-3-(5,6-二氫-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的1型和2型多晶型物。本發明還涉及具有超過99%手性純度的(-)-反式-3-(5,6-二氫-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物，和製備這些化合物的方法。本發明還涉及包含這些(-)-反式-3-(5,6-二氫-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物的藥物組合物。本發明提供了治療細胞增殖性病症例如癌症的方法，其通過給有此需要的受試者施用治療有效量的包含具有超過99%手性純度的(-)-反式-3-(5,6-二氫-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的組合物、或(-)-反式-3-(5,6-二氫-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的1型和2型多晶型物實施。
