CROSS, DARREN ANTHONY EDWARD,EBERLEIN, CATHERINE ANNE
申请号：
CA2943402
公开号：
CA2943402A1
申请日:
2015.04.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to the methods for identifying resistance to cancer therapy, by identification of an E63K NRAS mutation, a G12V NRAS mutation or a gain of copy number of NRAS gene. A further aspect of the invention relates to methods of treatment that may overcome such resistance mechanisms, involving the use of an EGFR inhibitor in combination with a MEK inhibitor for the treatment of cancers involving an NRAS mutation selected from E63K, G12V, G12R, G12A, G12D, G12S and G12C, and/or cancel- involving a gain of copy number of NRAS gene.
