TESAR, MICHAEL,ELLWANGER, KRISTINA,FUCEK, IVICA,REUSCH, UWE,ROSS, THORSTEN,KOCH, JOACHIM,RAJKOVIC, ERICH,TREDER, MARTIN
申请号：
CA3095373
公开号：
CA3095373A1
申请日:
2019.04.12
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.
