Michael Tesar;Kristina Ellwanger;Ivica Fucek;Uwe Reusch;Thorsten Ross;Joachim Koch;Erich Rajkovic;Martin Treder
发明人:
Michael Tesar,Kristina Ellwanger,Ivica Fucek,Uwe Reusch,Thorsten Ross,Joachim Koch,Erich Rajkovic,Martin Treder
申请号：
US16714396
公开号：
US20200109202A1
申请日:
2019.12.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (FcγRIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.
