Robert Laird Judson;Deepa Subramanyam;Robert Blelloch;Yangming Wang;Collin Alfred Melton
发明人:
Robert Blelloch,Robert Laird Judson,Deepa Subramanyam,Collin Alfred Melton,Yangming Wang
申请号：
US13260904
公开号：
US20120134966A1
申请日:
2010.04.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.
