Tang, Jiansheng,Cal, Shenshen,Katkade, Bhushan,Schumacher, William,Miller, Kenneth J.
申请号：
AU2018203157
公开号：
AU2018203157A1
申请日:
2018.05.07
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018203157A120180524.pdf#####ABSTRACT A transdermal drug delivery device is disclosed for administering an oxidizably and/or hydrolyzably degradable drug, e.g., cholinesterase inhibitors such as rivastigmine. The device comprises a) a substantially impermeable backing layer； b) an adhesive layer substantially free of antioxidant and containing a therapeutically effective amount of the degradable drug, which adhesive drug-containing layer is capable of adhering directly to a subject's skin or to another adhesive layer which is capable of adhering to a subject's skin； and c) a substantially impermeable protective release liner layer which releasably contacts the adhesive drug-containing layer or another adhesive layer. The delivery device is sealed in a degradation protective packaging system, such as a substantially oxygen impermeable heat sealable plastic pouch that contains a substantially inert gas and/or a degradation protectant material for the drug, such as an antioxidant, which can be inserted separately to the pouch. A method of making the device is also provided.
