TRANSDERMAL DISPENSING DEVICE, AND METHODS FOR PREPARING AN ADHESIVE MATRIX, FOR REMOVING CRYSTALIZATION NUCLEARS AND RESTORING THE INTERNAL ADHESIVE ADHESIVE DEVICE FOR A TRANSDEMIC MEDICINE AND DEVICE.
JIANSHENG TANG,JOSEPH M. DEVERICH,KENNETH J. MILLER,RUSSEL D. BESTE
申请号：
BRPI0808864
公开号：
BRPI0808864A2
申请日:
2008.03.11
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
