Hans-Georg LERCHEN,Lars LINDEN,Sherif EL SHEIKH,Jörg WILLUDA,Charlotte C. KOPITZ,Joachim SCHUHMACHER,Simone GREVEN,Christoph MAHLERT,Beatrix STELTE-LUDWIG,Sven GOLFIER,Rudolf BEIER,Iring HEISLER,Axel
申请号：
US15052655
公开号：
US20160193359A1
申请日:
2016.02.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
