Hans-Georg Lerchen,Lars Linden,Sherif El Sheikh,Willuda Willuda,Charlotte Christine Kopitz,Joachim Schuhmacher,Simone Greven,Christoph Mahlert,Beatrix Stelte-Ludwig,Sven Golfier,Rudolf Beier,Iring Hei
申请号：
US13656681
公开号：
US20130095123A1
申请日:
2012.10.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
