BROWN Matthew Frank,DERMENCI Alpay,FENSOME Andrew,GERSTENBERGER Brian Stephen,HAYWARD Matthew Merrill,OWEN Dafydd Rhys,WRIGHT Stephen Wayne,XING Li Huang,YANG Xiaojing
申请号：
MDE20190031
公开号：
MD3419978T2
申请日:
2017.02.10
申请国别(地区):
MD
年份:
2020
代理人:
摘要：
A compound having the structure (I) or an acceptable pharmaceutical salt thereof, or an acceptable pharmaceutical solvent of that compound, or an acceptable pharmaceutical salt, is proposed,in which: A, A'and A' independently represent O, C=O, C-R'or N-R',where R'and R' independently may represent H, amino, -NR7COR6, COR6, -CONR7R8, C1-C6 alkyl or hydroxy (C1-C6 alkyl) and R'may be present or absent, and is present where the validity rules allow and where no more than one of A, A' and A'represents O or C=O； Ro and R independently represent H, Br, CI, F or C1-C6 alkyl； R1 is H, C1-C6 alkyl or hydroxy(C1-C6 alkyl)；R2 is selected from the group of H, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6 alkyl),phenyl(C1-C6 alkyl),straight, heterheterheterheterheterhetercyclic, COR6, -OCOR6, -COOR6, -NRNR7COR6, -CONRR8 and -(CH2)n-heterheterheterheterheterheterheterheterheterheterheterheterhetero-cyclior hetercyclicyclic, heterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterhetero-cyclicyclic, heterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterhetero-cyclicyclicyclicyclicyclicyclicyclicyclical, heterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterheterhetercyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicyclicycliYeah. substituted or substituted for halo, cyanide, hydroxy or C1-C6 alkyl； X is C-R3 or N, where R3 may be H or C1-C6 alkyl； R4 and independent R5 are H, amino, C1-C6 alkyl or hydroxy(C1-C6 alkyl)；R6, R7 and R8 each independent represents H, C1-C6 alkyl, C1-C4 alkyl(C1-C6 alkyl) or C3-C8 cycloalcyl, C1-C6 alkyl is optionally substituted with halo, CN or hydroxy； or R7 and R8 together with the related atom form a ring with 5- or 6-memb
