JEAN CLAUDE ORTUNO,ALEXIS CORDI,JEAN MICHEL LACOSTE,IMRE FEJES,MICHAEL BURBRIDGE,JOHN HICKMAN,ALAIN PIERRE
申请号：
IN1736/DEL/2010
公开号：
IN300362B
申请日:
2010.07.26
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Dihydroindolone derivatives (I) and their optical and geometric isomers, or addition salts with an acid or base are new. Dihydroindolone derivatives of formula (I) and their optical and geometric isomers, or addition salts with an acid or base are new. m : 1 or 2 n : 1 or 2 A : a pyrrolyl group optionally substituted by 1-3 groups of 1-6C alkyl X : C(O), S(O) or SO 2 either R 1>, R 2> : 1-6C alkyl or NR 1>R 2> : a heterocyclic group R 3>R 4> : a heterocyclic group R 5> : H or 1-6C alkyl and R 6> : H or halo, where the heterocyclic group is a mono or bicyclic 5-8 membered group (optionally containing one to three heteroatoms of N, O or S, and one or more unsaturations, and optionally substituted by one or more 1-6C alkyl, 1-6C alkenyl, oxo, hydroxy, 1-6C alkoxy, aryl, arylalkyl or arylalkenyl), the aryl is phenyl group optionally substituted by one or more halo or 1-6C alkyl, and X represents the double bond, which is in configuration is Z or E. Independent claims are included for: (1) the preparations of (I) and (2) combination comprising (I) with an anticancer agent comprising genotoxic agents, mitotic poisons, antimetabolites, proteasome inhibitors or kinase inhibitors. Image ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given. EP2281822A1
