Holly Dressler,Kyriakos D. Economides,Zhen Pang,Harry Gregory Polites
申请号：
US13516077
公开号：
US20120255041A1
申请日:
2010.12.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway modulation following ligand binding of GPCR receptors.
