Holly DRESSLER,Kyriakos D. ECONOMIDES,Zhen PANG,Harry Gregory POLITES
申请号：
US14613810
公开号：
US20150208623A1
申请日:
2015.02.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway following ligand binding of GPCR receptors.
