The Board of Trustees of the Leland Stanford Junior University
发明人:
Jun Woo Kim,Jennifer R. Cochran,Eric Alejandro Sweet
申请号：
US16465754
公开号：
US20190359683A1
申请日:
2017.12.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are agents that specifically bind a ligand of ciliary neurotrophic factor receptor (CNTFR). In certain aspects, an agent of the present disclosure is a soluble CNTFR polypeptide. The soluble CNTFR polypeptide may have an altered (e.g., reduced) binding affinity for one or more ligand-CNTFR complex subunits, an altered (e.g., increased) binding affinity for one or more CNTFR ligands, or any combination thereof. Compositions that include the agents of the present disclosure are also provided, as are methods of using the agents (e.g., for treating a cell proliferative disorder) and methods of identifying an individual as having a cell proliferative disorder associated with CNTFR signaling.
