THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
HAY, MEREDITH,KONHILAS, JOHN,POLT, ROBIN L.,JONES, EVAN,SZABO, LAJOS
申请号:
CA2955656
公开号:
CA2955656A1
申请日:
2015.07.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.