ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
Meredith Hay,John Konhilas,Robin L. Polt,Todd Vanderah,Brittany Forte,Tally Milnes,Evan Jones,Lajos Szabo
申请号：
US16208731
公开号：
US20190351009A1
申请日:
2018.12.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
