Motoki Takagi,Akira Shimamoto,Yasuhiro Furuichi,Ayumi Sato
申请号：
US11791129
公开号：
US08314073B2
申请日:
2005.11.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present inventors discovered that although suppressing expression of the RecQ1 gene, a RecQ helicase family gene, shows suppressive effects on cell proliferation in cancer cells, such effects are not observed in human TIG3 cells (a normal diploid fibroblast cell line), which are normal cells. Hence, the present inventors discovered that siRNAs against RecQ1 gene have cancer cell-specific cell proliferation-suppressing effects that are mediated by suppression of the expression of said gene.
