The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).本發明係關於在類澱粉蛋白或類澱粉狀蛋白質所引起或相關之疾病及病症之治療中，用於治療及診斷用途的方法及組合物，該等疾病及病症包括澱粉樣變性病，一群與類澱粉蛋白質相關之病症及異常，諸如阿茲海默氏病(Alzheimer's disease)。本發明提供包含高特異性及高度有效抗體之新穎方法及組合物，該等抗體具有特異性識別及結合一範圍之β-類澱粉蛋白質之特定抗原決定基(epitopes)的能力。藉由本發明之教示所獲得之抗體尤其可用於治療類澱粉蛋白或類澱粉狀蛋白質所引起或相關之疾病及病症，包括澱粉樣變性病，一群與類澱粉斑塊形成相關之疾病及病症，包括繼發性澱粉樣變性病及與年齡相關之澱粉樣變性病，包括(但不限於)神經學病症，諸如阿茲海默氏病(AD)。
