ANDREA PFAJFER,MARIJA PIL'GREN,ANDREAS MUS,RAJAN UOTTS,Андреа ПФАЙФЕР,MARIJA PILGREN,Мария ПИЛЬГРЕН,Андреас МУС,Райан УОТТС
申请号：
RU2010100354
公开号：
RU2571856C2
申请日:
2008.06.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: bioengineering.SUBSTANCE: options of immune body or its epitope-linking fragment, that are specific in terms of beta amyloid peptide 1-40 are suggested. Each option is characterized in that contains areas VH and VL, or 6 CDR out of light and heavy chains. Described: coding nucleic acid； options of repository lines of cells (hybrid) with collection numbers DSM ACC2844, DSM ACC2845, DSM ACC2846, and line of cells including said polynucleotide, to receive immune bodies. Suggested: therapeutic composition to treat diseases or distresses due to or linked with amyloid or amyloid-like proteins, and set to determine amyloid protein in the biologic sample, - using immune body. Options of method of immune body production are described: with use of hybrid and coding nucleic acid. Described: method of diagnostic of aptitude for disease or state linked with amyloidosis； method of determination of degree of content of amyloidogenic plaque in the tissue； method of monitoring of minimum residual disease linked with amyloid； method of forecast of individual sensibility； method of treatment or alleviation of the diseases linked with amyloidosis； method of decreasing of number of plaque and their load in brain； mewthod of decreasing of total number of soluble protein of amyloid, and method of keeping or increasing of cognitive memory volume of the individual - using immune body or its epitope-linking fragment. Options of use of immune body or its epitope-linking fragment for medicament production are described.EFFECT: new immune bodies that can be used in therapy and diagnostic of Alzheimer's disease and other listed amyloidosises.54 cl, 20 dwg, 13 tbl, 3 exНастоящее изобретение относится к иммунологии и биотехнологии. Предложены варианты антитела или его эпитоп-связывающего фрагмента, специфичных в отношении бета-амилоидного пептида 1-40. Каждый из вариантов характеризуется тем, что включает области VH и VL, либо 6 CDR из лёгкой и тяжёлой цепи. Описаны: кодирующая НК； вариан
