HOEKMAN, JOHN D.,SATTERLY, KELSEY H.,SHREWSBURY, STEPHEN B.,YOUMANS, SCOTT B.,FULLER, CHRISTOPHER
申请号：
CA3088942
公开号：
CA3088942A1
申请日:
2019.01.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (Cmax) of at least 750 pg/ml, (b) with a mean time to Cmax (Tmax) of DHE of less than 45 minutes, and (c) a mean plasma AUCo-inf of DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.
