WATER SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES

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专利权人:

Yeda Research and Development Co. Ltd.

发明人:

Avigdor SCHERZ,Alexander BRANDIS,Ohad MAZOR,Yoram Salomon,Hugo SCHEER

申请号：

US14504347

公开号：

US20150238773A1

申请日:

2014.10.01

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<；->；, COS<；->；, SO3<；->；, PO3<；2->；, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17<；3>；, 13<；3>；, and 3<；2>； of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

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