A kind of pressure controller of phlegm extraction device, it include mainly a valve seat and a control valve, valve seat has a groove, control valve axially displaceably and rotationally sets what valve seat and has a convex block, when the convex block of control valve corresponds to the radial groove of what valve seat, control valve can be pressed to switch the gas circulation status in valve seat, pumping phlegm operation is set to go on smoothly, when being mutually staggered between the convex block of control valve and the groove of valve seat, control valve can not be pressed, and can be prevented unexpected accidentally touching at this time and be achieved the effect that promote safety in utilization.一種抽痰裝置之壓力控制器,主要包含有一閥座及一控制閥,閥座具有一凹槽,控制閥可軸向移動地且可轉動地設於閥座且具有一凸塊,當控制閥之凸塊對應於閥座之徑向凹槽時,控制閥可以被按壓來切換閥座內的氣體流通狀態,使抽痰作業能夠順利進行,當控制閥之凸塊與閥座之凹槽之間相互錯開時,控制閥無法被按壓,此時可以防止意外誤觸而達到提升使用安全性的效果。