A cage or enclosure is provided for irreversibly locking around at least a portion of a catheter hub or other medical article to inhibit access to a lumen through the catheter hub. The cage includes a base, a cover, and a latching mechanism. The cage can further include a hinge. When open, a receptacle formed by the cage is accessible for receiving the catheter hub. When closed, the latching mechanism prevents the cage from being opened unless the latching member is cut-off the cage or the cage is visibly damaged. The cage could be used on a variety of medical articles including: a needleless valve or connector an overlying cap on top of the valve or connector administration tubing a side port or connector on the side port and any overlying cap on the side port or connector.
