A sheath is provided for enclosing at least a portion of a catheter hub or other medical article to inhibit access to a lumen through the catheter hub. The sheath may comprise one or more portions that can be folded, wrapped, or otherwise positioned over or around the catheter assembly. The sheath could be used on a variety of medical articles including: a needleless valve or connector； an overlying cap on top of the valve or connector； administration tubing； a side port or connector on the side port； and any overlying cap on the side port or connector.
