DAVIES, STEPHEN JOHN,BAKER, KENNETH WILLIAM JOHN,PHILPS, OLIVER JAMES,MOFFAT, DAVID FESTUS CHARLES,PATEL, SANJAY RATILAL
申请号：
AU2007310604
公开号：
AU2007310604B2
申请日:
2007.10.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compound of formula (I) are inhibitors of Polo-like kinases (PLKs), and are useful in treatment of cell proliferative diseases: wherein R and R are hydrogen, or an optionally substituted (C-C)alkyl, (C2- C)alkenyl, (C-C)alkynyl or (C-C)cycloalkyl group； R and R' are independently selected from hydrogen, -CN, hydroxyl, halogen, optionally substituted (C-C) alkyl, (C- C)alkenyl, (C-C)alkynyl or (C-C)cycloalkyl, -NRR or C-C alkoxy, wherein R and R are independently hydrogen or optionally substituted (C-Calkyl； ring A is an optionally substituted mono- or bi-cyclic carbocyclic or heterocyclic ring or a ring system having up to 12 ring atoms； T is a radical of formula R-L -Y- wherein R is an alpha amino acid or alpha amino acid ester motif, linked to ring A by linker R-L-Y- as defined in the claims.
