LI, Peng,WENNOGLE, Lawrence P.,ZHAO, Jun,ZENG, Hailin
申请号：
ES09830742
公开号：
ES2580759T3
申请日:
2009.12.07
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formulas II-A or II-B: ** Formula ** in which (i) Q is C (>； = O)； (ii) R1 is H or C1-6 alkyl (for example, methyl or ethyl)； (iii) R2 is H, C1-6 alkyl (for example, isopropyl, isobutyl, 2-methylbutyl, 2,2-dimethylpropyl) wherein said alkyl group is optionally substituted with halo (for example, fluorine) or hydroxy (for example , 1-hydroxypropan-2-yl, 3-hydroxy-2-methylpropyl), for example, R2 may be trifluoromethyl or 2,2,2-trifluoroethyl, or GJ wherein G is a single bond or methylene； and J is 1-methylpyrrolidin-2-yl, or 1-methylpyrrolidin-3-yl (iv) R3 is 1) attached to the nitrogen of the pyrrolo part of Formula I and is a remainder of Formula A ** Formula * * in which X, Y and Z are C, and R8, R9, R11 and R12 are H； and R 10 is halogen, C 1-6 alkyl, C 1-6 alkoxy (for example, methoxy), C 3-8 cycloalkyl, C 3-8 heterocycloalkyl (for example, pyrrolidinyl or piperidinyl), C 1-6 haloalkyl (for example, trifluoromethyl), aryl (for example, phenyl), heteroaryl (for example, pyridyl, (for example, pyrid-2-yl) or, for example, thiadiazolyl (for example, 1,2,3-thiadiazol-4-yl), diazolyl, triazolyl (for example, 1,2,4-triazol-1-yl), tetrazolyl (for example, tetrazol-5-yl), alkoxadiazolyl (for example, 5-methyl-1,2,4-oxadiazole), pyrazolyl ( for example, pyrazol-1-yl), wherein the aryl, heteroaryl, cycloalkyl or heterocycloalkyl are optionally substituted with one or more C1-6 alkyl (for example, methyl), halogen (for example, chlorine or fluorine), C1 haloalkyl -6 (for example, trifluoromethyl), hydroxy, carboxy, -SH or an additional aryl or heteroaryl (for example, biphenyl or pyridylphenyl) preferably R10 is phenyl or pyridyl, for example, 2-pyridyl optionally substituted with a C1-6 alkyl, halogen, C1-6 haloalkyl, hydroxy, carboxy, -SH or an additional aryl or heteroaryl； (v) R4 and R5 are independently H, C1-6 alkyl (for example, methyl, isopropyl), aryl (for example, phenyl) or wherein said aryl is further substituted with halo (for example, 4-fluoro
